This is sort of a minor thing, but it always kinda bothered me that the Boss is referred to by neutral pronouns (they/their/them), like he/she's some sorta...weird alien creature or something. I mean, I understand it'd be a pain to record the same line twice just for a pronoun, but still. Sometimes, the game also slips up and uses male pronouns, even if the Boss is female (like in the beginning of the Gat loyalty mission in SRIV, and I think one of Dane's audio logs in GOOH). Kinda breaks the immersion.
Now, I'm not gonna be rioting Volition HQ or anything if the Boss/whoever the protagonist will be in SR5 is referred to by gender neutral pronouns again, but it'd be nice if that was changed.