Yeah I never found that aspect of SR3 funny or particularly entertaining, but simultaneously Agents of Mayhem had a lot of unfunny writing that missed the mark. The studio has demonstrated good writing in the past (and despite being essentially a standalone expansion pack 4 had a lot of excellent character moments), but how the writing ends up is definitely one of my biggest concerns.
There is a huge difference between crude humour, which is totally fine, but isn't inherently funny or clever, and actively stifling or self censoring based on supposed moral prejudices and biased sensibilities. If they censor the character creator, for example, that will be disappointing to me.
As is thoroughly demonstrated by the modding communities and fandoms for The Sims, Bethesda Games, VRchat, Cyberpunk, Final Fantasy, and various art communities, there is a huge audience of women who are incredibly supportive of sex positive character portrayals, and there is a strong potential market looking for good character customization in gaming that has been severely under-served.
I'm totally fine with a change in tone in regards to the style of humour and crude jokes, not because there is anything inherently immoral about that, but just in the hopes of good writing, characters and fun storytelling. But I will definitely be saddened if the new title has regressed in its portrayal of sexuality and its exploration of mature elements of the cityscape and world building, because essentially every triple A game in the last two generations doesn't treat their consumers like adults.