I hope they will continue with our Boss and Co.
I know probably a new protagonist will be customizable just like our Boss, but I like the Boss also as character, not only as avatar.
I don't want any remake. References are fine, remakes would be disappointing. I may accept an updated version of Rs1 because I hadn't occasion to play it, but I don't want a remake of anything. But I don't want a new saints gang either.
More character development.
I see the romance thing a bit out of place, not that I haven't appreciated, but in previous games, since the Boss can be either male or female, they made him not very sexually active, so seeing him asking for sex (and being awkward) to his friend seems a bit out of place. especially seeing that most of the time his friend make the first move. Just because the game is 18+, doesn't mean that the protagonist must be a sex-machine.
I also wish the Boss will be able to do more things when free-roaming (drinking, eating, sleeping, swimming underwater etc...)