For anyone that is playing this now i will share the issues i had and solutions for them. (Some are vanilla, not related to the modpack)
Invisible character, creation screen. You can just accept default look, save and restart the game, and your character wont be invisible. You can change your gender and look later at plastic surgery fine. Or you can install the modpack after character creation.
Car sound glitch. No sound at all, or random max volume sounds for no reason, that only stops if you fully stop. In Nvidia Manage 3d settings change vertical sync to "Fast" for that game.
Low fps, stuttering cinematics/cutscene. Also change vsync to fast.
The Ho Boat mission crash during the helicopter flight. Run the game through directx 9 executable for this mission and then you can go back to dx11 exe.
Some missions are problematic because of heavy trucks mechanics or melee of OP changed citiziens, that hitlock you so you can't move. First one is bad for escort missions, where the car is easily oneshoted by garbage truck. Second one is especially bad in missions where you dont have any offensive weapon, and can't fight back. No fix for that, you would have to delete the specific mods npc behavior.