It should work with vanilla saves and is compatible with all released DLCs... Are you from Australia? Censored Australian version of the game isn't compatible with most of mods.I'm having an issue right now, I keep crashing when I load up my save. Is it okay to install mid-game? I did a fresh install of SR IV and then got this, so it isn't a mod conflict.
Edit: I have the game and all DLC on Steam, if that matters.
Edit 2: Here's my folder currently. Is there something wrong with it? I seriously can't figure this out. Very confusing. If I remove it, I can play just fine. If I install it, I crash as soon as I begin to load my save.