I've played both. My first playthroughs of SR2, SRTT and SRIV were as a female character. The same character actually: my polar opposite. A publicly outspoken, sociopathic, shoot first-ask later, smoking hot red head that still resembles me somewhat(I am a guy, BTW). My second playthroughs are always male, but I play different characters inspired by those I used to play as in D&D. I'm currently attempting to make a SRIV character that resembles Nolan North for my second playthrough, since Nolan is basically playing himself in the game.